Cdh15 Gene Summary [Mouse]

This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion and regulate many morphogenetic events during development. The encoded preproprotein is further processed to generate a mature protein. Based on the expression of this gene in skeletal muscle, satellite cells and cerebellum, it was postulated that the encoded protein may be important for muscle development and regeneration. Mice lacking the encoded protein appear normal and display no discernible defects in skeletal musculature. Multiple distinct genes of the cadherin family, including this gene, are found on chromosome 8. [provided by RefSeq, Nov 2015]

Details

Type
Protein Coding
Official Symbol
Cdh15
Official Name
cadherin 15 [Source:MGI Symbol;Acc:MGI:106672]
Ensembl ID
ENSMUSG00000031962
Bio databases IDs NCBI: 12555 Ensembl: ENSMUSG00000031962
Aliases cadherin 15
Synonyms cadherin 15, CDH14, CDH3, CDHM, MCAD, M-cadherin, MRD3, Muscle-cadherin precursor
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdh15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Cadherin, Y-type LIR-motif
  • Cadherin repeat-like domain
  • protein binding

Pathways

Biological processes and signaling networks where the Cdh15 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • critical COVID-19
  • autosomal dominant mental retardation type 3
  • mental retardation
regulated by
regulates
role in cell
  • adhesion

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • Nucleus
  • Golgi Apparatus
  • cell-cell contacts
  • caveolae
  • neuromuscular junctions
  • neurites
  • axons

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdh15 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • calcium-dependent cell-cell adhesion
  • cell-cell junction assembly
  • adherens junction organization
  • multicellular organismal development
  • cell-cell adhesion mediated by cadherin
  • cell morphogenesis
  • cell adhesion
  • homophilic cell adhesion
  • cell migration

Cellular Component

Where in the cell the gene product is active
  • adherens junction
  • caveola
  • extracellular vesicular exosome
  • neuromuscular junction
  • Golgi apparatus
  • catenin complex
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • calcium ion binding
  • cadherin binding
  • beta-catenin binding

Gene-Specific Assays for Results You Can Trust

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