Snx1 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in neuron projection development. Acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway. Located in several cellular components, including dendritic spine; early endosome; and postsynaptic density. Is active in postsynaptic density, intracellular component. Is extrinsic component of postsynaptic endosome membrane. Is expressed in several structures, including egg cylinder and small intestine. Orthologous to human SNX1 (sorting nexin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx1 |
| Official Name | sorting nexin 1 [Source:MGI Symbol;Acc:MGI:1928395] |
| Ensembl ID | ENSMUSG00000032382 |
| Bio databases IDs | |
| Aliases | sorting nexin 1 |
| Synonyms | HsT17379, sorting nexin 1, VPS5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- insulin receptor binding
- amphipathic helix
- Vps5 C terminal like
- epidermal growth factor receptor binding
- Sorting nexin, N-terminal domain
- coiled-coil domain
- receptor binding
- protein binding
- Bin/Amphiphysin/Rvs domain
- identical protein binding
- phosphatidylinositol binding
- protein homodimerization
- tail domain
- The Phox Homology domain, a phosphoinositide binding module
- PX domain
- protein heterodimerization
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- COVID-19
- growth failure
- exencephaly
- Waldenström macroglobulinemia
- colon epithelial cancer
- colon carcinoma
- endometrial cancer
role in cell
- apoptosis
- expression in
- adhesion
- phosphorylation in
- degradation in
- proliferation
- formation
- binding in
- accumulation in
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membrane-bounded organelle
- organelle
- presynaptic regions
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- cytoplasmic aggregates
- cytosol
- endosomal compartment
- endosomal membrane
- dendritic spines
- early endosomes
- endocytotic vesicle
- postsynaptic density
- macropinosomes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lamellipodium morphogenesis
- early endosome to Golgi transport
- intracellular protein transport
- retrograde transport, endosome to Golgi
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- Golgi apparatus
- lysosome
- early endosome membrane
- endosome
- cytoplasm
- intracellular membrane-bounded organelle
- retromer complex, outer shell
- membrane
- retromer complex
- vesicle
- cytosol
- macromolecular complex
- endosome membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- cadherin binding
- phosphatidylinositol binding
- epidermal growth factor receptor binding
- insulin receptor binding