Snx6 Gene Summary [Mouse]
Enables type I transforming growth factor beta receptor binding activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels. Is active in glutamatergic synapse and postsynaptic early endosome. Is expressed in brain; cerebral cortex ventricular layer; and cortical plate. Orthologous to human SNX6 (sorting nexin 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snx6 |
| Official Name | sorting nexin 6 [Source:MGI Symbol;Acc:MGI:1919433] |
| Ensembl ID | ENSMUSG00000005656 |
| Bio databases IDs | |
| Aliases | sorting nexin 6 |
| Synonyms | 2010006G21Rik, 2610032J07Rik, 2810425K19Rik, MSTP010, sorting nexin 6, TFAF2, TRAF4 ASSOCIATED FACTOR 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snx6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoskeletal protein binding
- Vps5 C terminal like
- transforming growth factor-beta receptor binding
- protein homodimerization
- coiled-coil domain
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- Bin/Amphiphysin/Rvs domain
- PX domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Alzheimer disease
- neonatal late-onset sepsis
- infection by Listeria monocytogenes EGD-e
role in cell
- apoptosis
- expression in
- accumulation in
- formation
- detachment
- formation in
- replication in
- loss in
- detachment in
- recovery in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cell periphery
- Nucleus
- endosomes
- vesicles
- lysosome
- cytoplasmic aggregates
- endosomal membrane
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snx6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- negative regulation of epidermal growth factor-activated receptor activity
- cellular response to epidermal growth factor stimulus
- regulation of macroautophagy
- intracellular protein transport
- retrograde transport, endosome to Golgi
- negative regulation of transforming growth factor beta receptor signaling pathway
- negative regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- nucleus
- endosome
- cytoplasm
- retromer complex, outer shell
- retromer complex
- cytosol
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- dynactin binding
- phosphatidylinositol binding
- type I transforming growth factor beta receptor binding