Adrb1 Gene Summary [Mouse]
Enables G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential and beta1-adrenergic receptor activity. Involved in positive regulation of cold-induced thermogenesis and regulation of circadian sleep/wake cycle, sleep. Acts upstream of or within several processes, including brown fat cell differentiation; diet induced thermogenesis; and regulation of systemic arterial blood pressure by norepinephrine-epinephrine. Located in membrane. Is active in Schaffer collateral - CA1 synapse and neuronal dense core vesicle. Is expressed in several structures, including brain; exocrine gland; hemolymphoid system gland; intestine; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adrb1 |
| Official Name | adrenergic receptor, beta 1 [Source:MGI Symbol;Acc:MGI:87937] |
| Ensembl ID | ENSMUSG00000035283 |
| Bio databases IDs | |
| Aliases | adrenergic receptor, beta 1 |
| Synonyms | ADRB1R, ADR-beta1, Adrenergic Receptor Beta 1, adrenergic receptor, beta 1, Adrenergic Receptor β 1, adrenergic receptor, β 1, adrenoceptor beta 1, adrenoceptor β 1, ADR-β1, B1AR, beta-1 adrenergic receptor, beta1-ADRENORECEPTOR, BETA1AR, beta2-AR, beta-AR, FNSS2, RATB1AR, RHR, β 1-adrenergic receptor, β1-AR, β2-AR, β-AR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adrb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Akt phosphorylation site
- G-protein-coupled receptor binding
- protein binding
- proline rich domain
- seven-transmembrane G protein-coupled receptor superfamily
- beta-adrenergic receptor
- PDZ-domain binding
- G protein-coupled receptor kinase phosphorylation site
- neurotransmitter receptor
- binding protein
- cytoplasmic loop
- transmembrane domain
- tail domain
- 7 transmembrane receptor (rhodopsin family)
- extracellular loop
- Pka phosphorylation site
- cytosolic tail domain
- beta1-adrenergic receptor
- protein heterodimerization
- G-protein binding domain
Pathways
Biological processes and signaling networks where the Adrb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Breast Cancer Regulation by Stathmin1
- Cardiac Hypertrophy Signaling
- Cardiac β-adrenergic Signaling
- Cellular Effects of Sildenafil (Viagra)
- Circadian Rhythm Signaling
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Gap Junction Signaling
- Gαs Signaling
- Myc Mediated Apoptosis Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Phagosome Formation
- Serotonin Receptor Signaling
- TR/RXR Activation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- diabetes mellitus
- advanced cancer
- cancer
- acute myeloid leukemia
- obesity
- plasma cell myeloma
- infection
- chronic renal impairment
- breast cancer
role in cell
- cell death
- apoptosis
- production in
- expression in
- phosphorylation in
- differentiation
- activation in
- binding in
- molecular cleavage in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- Cytoplasm
- cell surface
- cellular membrane
- lysosome
- apical cell surfaces
- basolateral cell surfaces
- caveolae
- neurites
- synapse
- early endosomes
- transverse tubules
- secretory granules
- membrane rafts
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adrb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of multicellular organism growth
- regulation of postsynaptic membrane potential
- fear response
- positive regulation of MAPK cascade
- diet induced thermogenesis
- vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
- brown fat cell differentiation
- response to cold
- heat generation
- positive regulation of heart rate by epinephrine-norepinephrine
- positive regulation of the force of heart contraction by epinephrine-norepinephrine
- adenylate cyclase-activating adrenergic receptor signaling pathway
- regulation of circadian sleep/wake cycle, sleep
Cellular Component
Where in the cell the gene product is active
- early endosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- beta-adrenergic receptor activity
- PDZ domain binding
- alpha-2A adrenergic receptor binding
- beta1-adrenergic receptor activity