Fbxo3 Gene Summary [Mouse]
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human FBXO3 (F-box protein 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo3 |
| Official Name | F-box protein 3 [Source:MGI Symbol;Acc:MGI:1929084] |
| Ensembl ID | ENSMUSG00000027180 |
| Bio databases IDs | |
| Aliases | F-box protein 3 |
| Synonyms | 1200002G09Rik, 1700026K02Rik, FBA, F-box protein 3, FBX3, LOC687307 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMI1 / KNR4 family (SUKH-1)
- F-box domain
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box-like
- protein binding activity, bridging
- ApaG domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- response to lipopolysaccharide
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- SCF ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding