Ube4a Gene Summary [Mouse]
Enables ubiquitin-ubiquitin ligase activity. Acts upstream of or within protein polyubiquitination. Located in cytoplasm. Is expressed in ganglia; medulla oblongata basal plate; thymus primordium; ventral grey horn; and vibrissa. Orthologous to human UBE4A (ubiquitination factor E4A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube4a |
| Official Name | ubiquitination factor E4A [Source:MGI Symbol;Acc:MGI:2154580] |
| Ensembl ID | ENSMUSG00000059890 |
| Bio databases IDs | |
| Aliases | ubiquitination factor E4A |
| Synonyms | 4732444G18Rik, 9930123J21Rik, Ab2-232, E4, NEDHMS, ubiquitination factor E4A, UBOX2, UFD2, UFD2b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube4a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- enzyme
- protein binding
- Ubiquitin elongating factor core
Pathways
Biological processes and signaling networks where the Ube4a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- major depression
- lung adenocarcinoma
- lung adenocarcinoma formation
- aortic valve calcification
- neurodevelopmental disorder
- neurodevelopmental disorder with hypotonia and gross motor and speech delay
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube4a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin-ubiquitin ligase activity