Kank1 Gene Summary [Mouse]
Predicted to enable beta-catenin binding activity. Predicted to be involved in several processes, including negative regulation of cellular component organization; negative regulation of substrate adhesion-dependent cell spreading; and regulation of signal transduction. Predicted to be located in nucleus and ruffle membrane. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including central nervous system; craniocervical region bone; limb; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 2. Orthologous to human KANK1 (KN motif and ankyrin repeat domains 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kank1 |
| Official Name | KN motif and ankyrin repeat domains 1 [Source:MGI Symbol;Acc:MGI:2147707] |
| Ensembl ID | ENSMUSG00000032702 |
| Bio databases IDs | |
| Aliases | KN motif and ankyrin repeat domains 1 |
| Synonyms | A930031B09RIK, ANKRD15, ANKYRIN REPEAT domain protein 15, AU015049, CPSQ2, D330024H06Rik, KANK, KIAA0172, KN motif and ankyrin repeat domains 1, LOC100505905, mKIAA0172 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kank1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- KN motif
- beta-catenin binding
- protein binding activity, bridging
- Ankyrin repeats (3 copies)
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- epithelial cancer
- skin neoplasia
- acute myeloid leukemia
- uterine leiomyoma
- leiomyomatosis
- skin neoplasm
- migraines
- HER2 negative hormone receptor negative breast cancer
- spastic quadriplegic cerebral palsy type 2
role in cell
- proliferation
- organization
- migration
- morphogenesis
- development
- orientation
- orientation in
- assembly
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell cortex
- Plasma Membrane
- membrane ruffles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kank1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- regulation of Rho protein signal transduction
- negative regulation of Rho protein signal transduction
- positive regulation of wound healing
- negative regulation of lamellipodium morphogenesis
- negative regulation of substrate adhesion-dependent cell spreading
- positive regulation of canonical Wnt receptor signaling pathway
- negative regulation of ruffle assembly
- negative regulation of insulin receptor signaling pathway
- negative regulation of actin filament polymerization
- negative regulation of neuron projection development
- positive regulation of Wnt receptor signaling pathway
- actin cytoskeleton organization
- negative regulation of cell migration
- regulation of establishment of cell polarity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- ruffle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-catenin binding