Upf2 Gene Summary [Mouse]
Predicted to enable telomeric DNA binding activity. Acts upstream of or within animal organ regeneration and liver development. Predicted to be located in several cellular components, including cytoplasmic ribonucleoprotein granule; cytosol; and perinuclear region of cytoplasm. Predicted to be part of exon-exon junction complex. Predicted to be active in cytoplasm. Is expressed in several structures, including liver; lung; pancreas; spleen; and testis. Orthologous to human UPF2 (UPF2 regulator of nonsense mediated mRNA decay). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Upf2 |
| Official Name | UPF2 regulator of nonsense transcripts homolog (yeast) [Source:MGI Symbol;Acc:MGI:2449307] |
| Ensembl ID | ENSMUSG00000043241 |
| Bio databases IDs | |
| Aliases | UPF2 regulator of nonsense transcripts homolog (yeast) |
| Synonyms | C76554, HUPF2, RENT2, smg-3, UPF2 regulator of nonsense mediated mRNA decay, UPF2, regulator of nonsense mediated mRNA decay, UPF2 regulator of nonsense transcripts homolog (yeast) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Upf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- eIF4G homology domain
- Up-frameshift suppressor 2
- MIF4G domain
- protein binding
- telomeric DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic steatosis
- inflexible behavior disorder
- neurodevelopmental disorder
- pervasive developmental disorder
- reactive astrogliosis
role in cell
- activation
- number
- survival
- cell survival
- josamycin sensitivity
- G1/S phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- perinuclear region
- Nucleus
- cytosol
- perinuclear space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Upf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- liver development
- organ regeneration
Cellular Component
Where in the cell the gene product is active
- nucleus
- exon-exon junction complex
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- telomeric DNA binding