Arhgdig Gene Summary [Mouse]
Enables GDP-dissociation inhibitor activity. Acts upstream of or within blastocyst hatching and regulation of protein localization. Located in membrane. Is expressed in several structures, including central nervous system; epithelium; gonad; trigeminal nerve; and upper jaw molar. Orthologous to human ARHGDIG (Rho GDP dissociation inhibitor gamma). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arhgdig |
| Official Name | Rho GDP dissociation inhibitor (GDI) gamma [Source:MGI Symbol;Acc:MGI:108430] |
| Ensembl ID | ENSMUSG00000073433 |
| Bio databases IDs | |
| Aliases | Rho GDP dissociation inhibitor (GDI) gamma |
| Synonyms | Gdi5, Rho-GDI2, RHOGDI-3, RHOGDI gamma, RHOGDI γ, Rho GDP dissociation inhibitor gamma, Rho GDP dissociation inhibitor γ, RIP2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arhgdig often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase regulator
- GDP-dissociation inhibitor
- Rho GDP-dissociation inhibitor
- protein binding
- RHO protein GDP dissociation inhibitor
Pathways
Biological processes and signaling networks where the Arhgdig gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- cytosol
- cytoplasmic vesicles
- Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arhgdig gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization
- negative regulation of cell adhesion
- blastocyst hatching
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- membrane
- cytoplasmic vesicle
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- Rho GDP-dissociation inhibitor activity
- GTPase activator activity