Grap2 Gene Summary [Mouse]
Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in regulation of MAPK cascade and signal transduction. Predicted to be located in cytosol; endosome; and nucleus. Predicted to be active in cytoplasm; nucleoplasm; and plasma membrane. Is expressed in brain; genitourinary system; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in hepatitis C. Orthologous to human GRAP2 (GRB2 related adaptor protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grap2 |
| Official Name | GRB2-related adaptor protein 2 [Source:MGI Symbol;Acc:MGI:1333842] |
| Ensembl ID | ENSMUSG00000042351 |
| Bio databases IDs | |
| Aliases | GRB2-related adaptor protein 2 |
| Synonyms | GADS, GRB2L, Grb2-related 2, GRB2-related adaptor protein 2, GRBLG, GrbX, Grf40, GRID, GRPL, MONA, P38 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- proline/glutamine rich region
- Src homology 2 (SH2) domain
- protein binding
- inserted domain
- proline rich domain
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Grap2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Klinefelter syndrome
- diabetic nephropathy
- Turner syndrome
role in cell
- phosphorylation in
- expression in
- apoptosis
- activation in
- proliferation
- differentiation
- number
- clonal expansion
- abnormal morphology
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- endosomes
- cytosol
- nucleoplasm
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of MAPK cascade
- signal transduction
- cell-cell signaling
- Ras protein signal transduction
Cellular Component
Where in the cell the gene product is active
- nucleus
- endosome
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding