Atg12 Gene Summary [Mouse]
Predicted to enable protein tag activity. Predicted to contribute to Atg8-family ligase activity. Involved in autophagosome assembly; negative regulation of defense response; and negative regulation of type I interferon production. Located in phagophore assembly site membrane. Part of Atg12-Atg5-Atg16 complex. Is expressed in central nervous system; dorsal root ganglion; heart; lower jaw molar; and retina. Orthologous to human ATG12 (autophagy related 12). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atg12 |
| Official Name | autophagy related 12 [Source:MGI Symbol;Acc:MGI:1914776] |
| Ensembl ID | ENSMUSG00000032905 |
| Bio databases IDs | |
| Aliases | autophagy related 12 |
| Synonyms | 4931423H11Rik, A330058M13RIK, APG12, APG12L, Atg12l, autophagy related 12, FBR93, HAPG12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atg12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubl1_cv_Nsp3_N-like
- protein binding
Pathways
Biological processes and signaling networks where the Atg12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection by HIV-1
role in cell
- cell death
- expression in
- apoptosis
- survival
- replication in
- binding in
- accumulation in
- accumulation
- assembly
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- cytosol
- nucleoplasm
- neurites
- autophagic vacuoles
- perikaryon
- phagosomes
- autophagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atg12 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- negative regulation of type I interferon production
- piecemeal microautophagy of nucleus
- negative regulation of innate immune response
- mitochondrion degradation
- macroautophagy
- negative regulation of defense response to virus
Cellular Component
Where in the cell the gene product is active
- pre-autophagosomal structure membrane
- intracellular membrane-bounded organelle
- Atg12-Atg5-Atg16 complex
- phagocytic vesicle membrane
- cytosol
- macromolecular complex
- autophagic vacuole
- autophagic vacuole membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- Atg8 ligase activity