Ier2 Gene Summary [Mouse]
Predicted to be involved in several processes, including neuron differentiation; positive regulation of transcription by RNA polymerase II; and response to fibroblast growth factor. Located in cytoplasm. Is expressed in several structures, including ear; forelimb bud; submandibular gland primordium; tooth; and vibrissa. Human ortholog(s) of this gene implicated in colorectal cancer and hepatocellular carcinoma. Orthologous to human IER2 (immediate early response 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ier2 |
| Official Name | immediate early response 2 [Source:MGI Symbol;Acc:MGI:104815] |
| Ensembl ID | ENSMUSG00000053560 |
| Bio databases IDs | |
| Aliases | immediate early response 2 |
| Synonyms | Ch1, CHX1, ETR101, ETR11, Growth factor-inducible, immediate early response 2, Pip92, T lymphocyte activated |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ier2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epileptic seizure
- organismal death
- breast cancer
- COVID-19
- psoriasis
- Ullrich congenital muscular dystrophy
- venous thromboembolism
regulates
- DNA endogenous promoter
- DNA promoter
- RNA polymerase II
- SPP1
role in cell
- senescence
- differentiation
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ier2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell motility
- neuron differentiation
- response to fibroblast growth factor stimulus
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding