Lrig2 Gene Summary [Mouse]
Enables signaling receptor binding activity. Acts upstream of or within several processes, including negative regulation of axon regeneration; negative regulation of membrane protein ectodomain proteolysis; and positive regulation of protein localization to cell surface. Located in growth cone; intracellular vesicle; and membrane. Is expressed in several structures, including branchial arch; central nervous system; eye; inner ear; and nasal pit. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human LRIG2 (leucine rich repeats and immunoglobulin like domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lrig2 |
| Official Name | leucine-rich repeats and immunoglobulin-like domains 2 [Source:MGI Symbol;Acc:MGI:2443718] |
| Ensembl ID | ENSMUSG00000032913 |
| Bio databases IDs | |
| Aliases | leucine-rich repeats and immunoglobulin-like domains 2 |
| Synonyms | 4632419I10RIK, BB096938, leucine-rich repeats and immunoglobulin-like domains 2, LIG-2, UFS2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrig2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- protein phosphatase 1 regulatory subunit 42
- immunoglobulin domain
- Immunoglobulin I-set domain
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- receptor binding
- Leucine Rich repeats (2 copies)
- Immunoglobulin like
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- psoriasis
- osteosarcomagenesis
- urofacial syndrome type 2
- global developmental delay
- osteosarcoma
- urofacial syndrome
regulated by
- vadimezan
role in cell
- apoptosis
- proliferation
- expression in
- phosphorylation in
- migration
- migration by
- development
- regeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cellular membrane
- vesicles
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrig2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- sensory perception of sound
- negative regulation of axon regeneration
- positive regulation of protein localization at cell surface
- membrane protein ectodomain proteolysis
- negative regulation of membrane protein ectodomain proteolysis
- innervation
- regulation of platelet-derived growth factor receptor signaling pathway
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- growth cone
- extracellular space
- cytoplasm
- extracellular matrix
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding