PEBP1 Gene Summary [Human]
This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | PEBP1 |
| Official Name | phosphatidylethanolamine binding protein 1 [Source:HGNC Symbol;Acc:HGNC:8630] |
| Ensembl ID | ENSG00000089220 |
| Bio databases IDs | |
| Aliases | phosphatidylethanolamine binding protein 1, Raf kinase inhibitory protein, hippocampal cholinergic neurostimulating peptide |
| Synonyms | HCNP, HCNPpp, HEL-210, HEL-S-34, HEL-S-96, LOC100506570, PBP, Pbp1, Pbpr, PEBP, Phosphatidylethanolamine-binding, phosphatidylethanolamine binding protein 1, RKIP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PEBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylethanolamine binding domain
- kinase binding
- lipid binding
- protein kinase binding
- phosphatidylethanolamine binding
- ATP binding
- enzyme binding
- protein binding
- receptor binding
- Phosphatidylethanolamine-binding protein
- PhosphatidylEthanolamine-Binding Protein (PEBP) domain
- mek binding domain
Pathways
Biological processes and signaling networks where the PEBP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- asthma
- septic shock
- heart failure
- experimentally-induced heart failure
- chronic sinusitis
- hepatitis B virus-related hepatocellular carcinoma
- androgenic alopecia
- aortic valve calcification
role in cell
- cell death
- proliferation
- phosphorylation in
- expression in
- apoptosis
- invasion
- activation in
- production in
- inhibition in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- dendrite tip
- cell surface
- cell borders
- Extracellular Space
- apical compartment
- cellular membrane
- Nucleus
- Plasma Membrane
- cytosol
- mitochondrial outer membrane
- dendritic spines
- synaptic vesicles
- perikaryon
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PEBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein kinase binding
- serine-type endopeptidase inhibitor activity
- phosphatidylethanolamine binding
- protein binding
- RNA binding
- enzyme binding