Eefsec Gene Summary [Mouse]
Enables several functions, including GTP binding activity; RNA binding activity; and translation elongation factor activity. Acts upstream of or within selenocysteine incorporation. Located in mitochondrion. Part of ribonucleoprotein complex. Orthologous to human EEFSEC (eukaryotic elongation factor, selenocysteine-tRNA specific). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eefsec |
| Official Name | eukaryotic elongation factor, selenocysteine-tRNA-specific [Source:MGI Symbol;Acc:MGI:2137092] |
| Ensembl ID | ENSMUSG00000033216 |
| Bio databases IDs | |
| Aliases | eukaryotic elongation factor, selenocysteine-tRNA-specific |
| Synonyms | EFSEC, eukaryotic elongation factor, selenocysteine-tRNA-specific, LOC105374097, mSelB, RGD1560552, sec, SELB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eefsec often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- translation elongation factor
- mRNA binding
- 50S ribosome-binding GTPase
- GTPase
- protein binding
- Elongation factor Tu domain 2
- translation regulator
- GTP binding
- Domain III of Elongation factor (EF) Tu (EF-TU) and related proteins
- Domain II of Elongation factor Tu (EF-Tu)-like proteins
- small GTP-binding protein domain
- translation elongation factor TU
- ribonucleoprotein binding
- Elongation factor Tu GTP binding domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- selenocysteine
- CYP51A1
- MSRB1
disease
- epithelial cancer
- endometrial carcinoma
- non-insulin-dependent diabetes mellitus
- gastroesophageal reflux
- asthma
- preterm birth
- hypospadia
- schizophrenia
- postnatal progressive microcephaly with seizures and brain atrophy
- prostatic carcinoma
role in cell
- endoplasmic reticulum-associated degradation in
- cohesion in
- cohesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eefsec gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- selenocysteine incorporation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- translation elongation factor activity
- GTPase activity
- ribonucleoprotein complex binding
- tRNA binding
- selenocysteine insertion sequence binding