Snap91 Gene Summary [Mouse]
Enables several functions, including 1-phosphatidylinositol binding activity; clathrin heavy chain binding activity; and protein kinase binding activity. Involved in clathrin coat assembly and neurotransmitter secretion. Predicted to be located in several cellular components, including neuronal cell body; postsynaptic density; and presynaptic active zone membrane. Predicted to be part of AP-2 adaptor complex. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; cytoplasmic vesicle; and parallel fiber to Purkinje cell synapse. Predicted to be extrinsic component of presynaptic endocytic zone membrane. Is expressed in several structures, including central nervous system; gut; limb; peripheral nervous system ganglion; and urinary system. Orthologous to human SNAP91 (synaptosome associated protein 91). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Snap91 |
| Official Name | synaptosomal-associated protein 91 [Source:MGI Symbol;Acc:MGI:109132] |
| Ensembl ID | ENSMUSG00000033419 |
| Bio databases IDs | |
| Aliases | synaptosomal-associated protein 91 |
| Synonyms | AP180, AP3, CALM, C-AP180, F1-20, mKIAA0656, synaptosomal-associated protein 91, synaptosome associated protein 91 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Snap91 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- Family of unknown function (DUF5585)
- protein kinase binding
- SH2-domain binding
- protein binding activity, bridging
- alpha helix
- enzyme binding
- clathrin binding
- protein binding
- phosphatidylinositol binding
- binding protein
- phosphatidylinositol-4,5-bisphosphate binding
- VHS, ENTH and ANTH domain superfamily
- phospholipase inhibitor
- DPF domain
Pathways
Biological processes and signaling networks where the Snap91 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- major depression
- bipolar disorder
- Alzheimer disease
- pervasive developmental disorder
- tonic-clonic seizure
- primary snoring
- refractive error
- growth failure
- age-related hearing loss
role in cell
- expression in
- accumulation in
- formation
- development
- transmission
- assembly
- endocytosis
- abnormal morphology
- clustering
- abnormal quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- presynaptic regions
- cellular membrane
- cytosol
- presynaptic membrane
- postsynaptic membrane
- synaptic vesicles
- growth cone
- synaptosomes
- synapse
- membrane processes
- perikaryon
- postsynaptic density
- axon terminals
- presynaptic terminals
- excitatory synapses
- clathrin-coated vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Snap91 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- clathrin-mediated endocytosis
- clathrin coat assembly
- synaptic vesicle budding from presynaptic membrane
- protein transport
- regulation of clathrin-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- coated pit
- clathrin-coated vesicle
Molecular Function
What the gene product does at the molecular level
- clathrin heavy chain binding
- protein kinase binding
- phosphatidylinositol-4,5-bisphosphate binding
- protein binding
- SNARE binding
- 1-phosphatidylinositol binding