Cplx1 Gene Summary [Mouse]
Enables lipid binding activity. Involved in regulation of vesicle-mediated transport and signal release. Part of SNARE complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; calyx of Held; and glutamatergic synapse. Is expressed in nervous system; retina; and tongue. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 63. Orthologous to human CPLX1 (complexin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cplx1 |
| Official Name | complexin 1 [Source:MGI Symbol;Acc:MGI:104727] |
| Ensembl ID | ENSMUSG00000033615 |
| Bio databases IDs | |
| Aliases | complexin 1 |
| Synonyms | 921-S, complexin 1, CPX1, CPX-I, CX I, DEE63, EIEE63 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cplx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- lipid binding
- Synaphin protein
- syntaxin-1 binding
- Complexin_NTD
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- major depression
- early infantile epileptic encephalopathy type 63
- seizures
- COVID-19
- medulloblastoma SHH subtype
- brain cancer
- ataxia
- asthenozoospermia
- neophobia
role in cell
- expression in
- apoptosis
- growth
- plasticity
- priming
- exocytosis by
- exocytosis
- transmission
- miniature excitatory postsynaptic currents in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- presynaptic regions
- cell surface
- postsynaptic region
- cytosol
- neurites
- synapse
- perikaryon
- dendrites
- axon terminals
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cplx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- insulin secretion
- synaptic transmission
- regulation of synaptic vesicle fusion to presynaptic membrane
- regulation of exocytosis
- synaptic vesicle exocytosis
- exocytosis
Cellular Component
Where in the cell the gene product is active
- terminal button
- SNARE complex
- cytosol
- synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
- perikaryon
- calyx of Held
Molecular Function
What the gene product does at the molecular level
- neurotransmitter transporter activity
- protein binding
- syntaxin binding
- SNARE binding