Cplx1 Gene Summary [Rat]
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | Cplx1 |
| Official Name | complexin 1 [Source:RGD Symbol;Acc:70944] |
| Ensembl ID | ENSRNOG00000000060 |
| Bio databases IDs | |
| Aliases | complexin 1 |
| Synonyms | 921-S, complexin 1, CPX1, CPX-I, CX I, DEE63, EIEE63 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cplx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- lipid binding
- Synaphin protein
- syntaxin-1 binding
- Complexin_NTD
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- major depression
- early infantile epileptic encephalopathy type 63
- seizures
- COVID-19
- medulloblastoma SHH subtype
- brain cancer
- ataxia
- asthenozoospermia
- neophobia
role in cell
- expression in
- apoptosis
- growth
- plasticity
- priming
- exocytosis by
- exocytosis
- transmission
- miniature excitatory postsynaptic currents in
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- presynaptic regions
- cell surface
- postsynaptic region
- cytosol
- neurites
- synapse
- perikaryon
- dendrites
- axon terminals
- presynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cplx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of neurotransmitter secretion
- insulin secretion
- synaptic transmission
- regulation of synaptic vesicle fusion to presynaptic membrane
- regulation of exocytosis
- synaptic vesicle exocytosis
- exocytosis
Cellular Component
Where in the cell the gene product is active
- terminal button
- SNARE complex
- cytosol
- synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex
- perikaryon
- calyx of Held
Molecular Function
What the gene product does at the molecular level
- neurotransmitter transporter activity
- protein binding
- syntaxin binding
- SNARE binding