Tlr13 Gene Summary [Mouse]
Enables identical protein binding activity and rRNA binding activity. Involved in innate immune response and toll-like receptor 13 signaling pathway. Acts upstream of or within MyD88-dependent toll-like receptor signaling pathway; regulation of MAPK cascade; and response to virus. Located in endosome. Is expressed in vibrissa. [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tlr13 |
| Official Name | toll-like receptor 13 [Source:MGI Symbol;Acc:MGI:3045213] |
| Ensembl ID | ENSMUSG00000033777 |
| Bio databases IDs | |
| Aliases | toll-like receptor 13 |
| Synonyms | AABR07039446.2, AI666735, Gm713, RGD1562655, toll-like receptor 13 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tlr13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein phosphatase 1 regulatory subunit 42
- rRNA binding
- Leucine rich repeat
- SEFIR domain
- BspA type Leucine rich repeat region (6 copies)
- protein binding
- TIR domain
- identical protein binding
Pathways
Biological processes and signaling networks where the Tlr13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Altered T Cell and B Cell Signaling in Rheumatoid Arthritis
- Colorectal Cancer Metastasis Signaling
- Communication between Innate and Adaptive Immune Cells
- Neuroinflammation Signaling Pathway
- Parkinson's Signaling Pathway
- Phagosome Formation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- laser induced choroidal neovascularization
- splenomegaly
- infection by vesicular stomatitis virus
- skin infection by Staphylococcus aureus
role in cell
- expression in
- activation in
- production in
- quantity
- transcription in
- bacterial burden
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- cellular membrane
- endosomes