Ccp110 Gene Summary [Mouse]
Involved in ciliary basal body organization; negative regulation of cilium assembly; and positive regulation of cilium assembly. Located in centriole and centrosome. Is expressed in several structures, including cerebral cortex; inner cell mass; and olfactory epithelium. Orthologous to human CCP110 (centriolar coiled-coil protein 110). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccp110 |
| Official Name | centriolar coiled coil protein 110 [Source:MGI Symbol;Acc:MGI:2141942] |
| Ensembl ID | ENSMUSG00000033904 |
| Bio databases IDs | |
| Aliases | centriolar coiled coil protein 110 |
| Synonyms | 6330503K22Rik, centriolar coiled-coil protein 110, Cep110, CP110, RGD1310509 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ccp110 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Calcium-dependent calmodulin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- coloboma
- persistent truncus arteriosus
- Huntington disease
- ventricular septal defect
- ductal breast carcinoma
- ductal breast cancer
- cleft palate
- preaxial polydactyly
- omphalocele
role in cell
- formation
- formation in
- quantity
- cell cycle progression
- morphology
- duplication
- abnormal morphology
- aneuploidy
- breakage
- anaphase catastrophe
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- daughter centriole
- centrosome
- centriole
- microtubule organizing centers
- cytosol
- pro-centriole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ccp110 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centrosome duplication
- centriole replication
- microtubule basal body organization
- regulation of cytokinesis
- positive regulation of flagellum assembly
Cellular Component
Where in the cell the gene product is active
- centrosome
- centriole
- cilium
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding