Polq Gene Summary [Mouse]
Enables DNA helicase activity and DNA-directed DNA polymerase activity. Involved in double-strand break repair via alternative nonhomologous end joining; negative regulation of double-strand break repair via homologous recombination; and somatic hypermutation of immunoglobulin genes. Acts upstream of or within DNA repair. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in site of double-strand break. Is expressed in embryo; heart; spleen; and testis. Orthologous to human POLQ (DNA polymerase theta). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Polq |
| Official Name | polymerase (DNA directed), theta [Source:MGI Symbol;Acc:MGI:2155399] |
| Ensembl ID | ENSMUSG00000034206 |
| Bio databases IDs | |
| Aliases | polymerase (DNA directed), theta |
| Synonyms | A430110D14Rik, DNA polymerase theta, DNA polymerase θ, POLtheta, polymerase (DNA directed), theta, polymerase (DNA directed), θ, POLθ, PRO0327 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- single-stranded DNA dependent ATP dependent DNA helicase
- DNA-directed DNA polymerase
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- chromatin binding
- enzyme
- helix-turn-helix domain
- protein binding
- magnesium ion binding
- identical protein binding
- carbon-oxygen lyase
- single-stranded DNA specific endodeoxyribonuclease
- DNA helicase
- DNA polymerase family A, 5'-3' polymerase domain
- damaged DNA binding
- RNA-directed DNA polymerase
- DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- DNA polymerase family A
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon adenocarcinoma
- rectum cancer
- epithelial cancer
- epithelial neoplasia
- liver cancer
- renal cell cancer
- colorectal carcinomagenesis
- head and neck squamous cell carcinoma
- cutaneous mastocytosis
- pancreatic cancer
regulates
- Immunoglobulin
- IgG
- IgM
- IgG1
role in cell
- formation
- formation in
- growth
- processing
- function
- sensitivity
- etoposide sensitivity
- assembly in
- radiosensitization
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Golgi Apparatus
- cytosol
- mitochondrial nucleoids
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA repair
- base-excision repair
- negative regulation of double-strand break repair via homologous recombination
- DNA duplex unwinding
- protein homooligomerization
- error-prone translesion synthesis
- RNA-dependent DNA replication
- replication fork processing
- response to DNA damage stimulus
- somatic hypermutation of immunoglobulin genes
- double-strand break repair
Cellular Component
Where in the cell the gene product is active
- site of double-strand break
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- chromatin binding
- damaged DNA binding
- single-stranded DNA specific endodeoxyribonuclease activity
- magnesium ion binding
- ATP binding
- DNA helicase activity
- DNA-directed DNA polymerase activity
- RNA-directed DNA polymerase activity
- protein binding
- 5'-deoxyribose-5-phosphate lyase activity
- single-stranded DNA-dependent ATP-dependent DNA helicase activity