Septin4 Gene Summary [Mouse]
Predicted to enable several functions, including GTP binding activity; identical protein binding activity; and magnesium ion binding activity. Involved in several processes, including flagellated sperm motility; hematopoietic stem cell homeostasis; and negative regulation of stem cell proliferation. Acts upstream of or within brain development; sperm capacitation; and sperm mitochondrion organization. Located in several cellular components, including axon terminus; perikaryon; and sperm annulus. Part of septin complex. Is expressed in several structures, including central nervous system; sensory organ; and testis. Orthologous to human SEPTIN4 (septin 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Septin4 |
| Official Name | septin 4 [Source:MGI Symbol;Acc:MGI:1270156] |
| Ensembl ID | ENSMUSG00000020486 |
| Bio databases IDs | |
| Aliases | septin 4 |
| Synonyms | ARTS, Bh5, BRADEION, Bradeion beta, Bradeion β, Brain protein H5, C17orf47, CE5B3, Cerebral protein-7, EG3-1RVC, EG3RVC, Gm11492, H5, hCDCREL-2, hucep-7, LOC689764, MART, Pnutl2, SEP4, SEPT4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Septin4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- P-loop
- GTP binding
- Domain of unknown function (DUF4655)
- GTPase
- enzyme
- protein binding
- structural molecule
- magnesium ion binding
- identical protein binding
- Septin
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Septin4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- preeclampsia
- cancer
- teratozoospermia
- Huntington disease
- asthenozoospermia
- glioblastoma
- glioblastoma cancer
- hairpin sperm flagellum
role in cell
- cell death
- proliferation
- migration
- formation
- apoptosis
- formation in
- function
- development
- abnormal morphology
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- motile cilia
- sperm annulus
- presynaptic regions
- Plasma Membrane
- Mitochondria
- cytosol
- mitochondrial outer membrane
- nucleoplasm
- sperm tail
- synapse
- cellular protrusions
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Septin4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron migration
- sperm motility
- positive regulation of apoptotic process
- apoptotic process
- positive regulation of protein ubiquitination
- protein localization
- spermatid differentiation
- regulation of apoptotic process
- regulation of exocytosis
- positive regulation of intrinsic apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- cell division site
- synaptic vesicle
- perikaryon
- mitochondrial outer membrane
- nucleoplasm
- septin ring
- dendrite
- nucleus
- sperm annulus
- mitochondrion
- cytosol
- septin complex
- axon
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- GTP binding
- identical protein binding
- protein binding
- GTPase activity
- structural molecule activity
- binding, bridging