Cacybp Gene Summary [Mouse]
Enables molecular adaptor activity; protein domain specific binding activity; and ubiquitin protein ligase binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Located in cytoplasm and nuclear envelope lumen. Part of SCF ubiquitin ligase complex. Is expressed in several structures, including alimentary system; genitourinary system; liver lobe; nervous system; and sensory organ. Orthologous to human CACYBP (calcyclin binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cacybp |
| Official Name | calcyclin binding protein [Source:MGI Symbol;Acc:MGI:1270839] |
| Ensembl ID | ENSMUSG00000014226 |
| Bio databases IDs | |
| Aliases | calcyclin binding protein |
| Synonyms | calcyclin binding protein, GIG5, hCacyBP, PNAS-107, S100A6BP, SIP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cacybp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CS domain
- ubiquitin protein ligase binding
- alpha-crystallin Hsps/p23-like
- protein homodimerization
- protein domain specific binding
- protein binding
- Siah interacting protein, N terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- tumorigenesis
- epithelial cancer
- colon carcinoma
- colon epithelial cancer
- hepatocellular carcinoma
- liver cancer
- obesity
- metabolic syndrome X
- peripheral arterial disease
role in cell
- proliferation
- polyubiquitination in
- binding in
- expression in
- degradation in
- differentiation
- number
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- cell cortex
- cytosol
- nucleoplasm
- perinuclear space
- nuclear envelope
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cacybp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
Cellular Component
Where in the cell the gene product is active
- beta-catenin destruction complex
- nucleus
- extracellular vesicular exosome
- cytosol
- SCF ubiquitin ligase complex
- nuclear envelope lumen
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein domain specific binding
- protein homodimerization activity
- protein binding
- ubiquitin protein ligase binding
- S100 protein binding