Fhod3 Gene Summary [Mouse]
Predicted to enable actin filament binding activity. Acts upstream of or within cardiac myofibril assembly; negative regulation of actin filament polymerization; and sarcomere organization. Predicted to be located in striated muscle thin filament. Predicted to be active in cytoplasm and cytoskeleton. Is expressed in several structures, including central nervous system; genitourinary system; gut; heart; and musculoskeletal system. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy. Orthologous to human FHOD3 (formin homology 2 domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Fhod3 |
| Official Name | formin homology 2 domain containing 3 [Source:MGI Symbol;Acc:MGI:1925847] |
| Ensembl ID | ENSMUSG00000034295 |
| Bio databases IDs | |
| Aliases | formin homology 2 domain containing 3 |
| Synonyms | A930009H06Rik, CMH28, FHOS2, Formactin2, formin homology 2 domain containing 3, mKIAA1695 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fhod3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology 2 Domain
- protein binding
- Formin N-terminal GTPase-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- side effect
- heart disease
- Alzheimer disease
- dilated cardiomyopathy
- thoracic aortic aneurysms and dissections
- hypertrophic cardiomyopathy
- periodontitis
- acne
- familial hypertrophic cardiomyopathy type 28
role in cell
- formation
- organization
- disruption
- hypertrophy
- formation in
- polymerization in
- polymerization
- myofibrillogenesis in
- integrity
- degeneration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- sarcomere
- myofibrils
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fhod3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cortical actin cytoskeleton organization
- sarcomere organization
- cardiac myofibril assembly
Cellular Component
Where in the cell the gene product is active
- Z disc
- cytoskeleton
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- protein binding