Cdc23 Gene Summary [Mouse]
Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; positive regulation of mitotic metaphase/anaphase transition; and protein polyubiquitination. Predicted to be part of anaphase-promoting complex. Is expressed in 4-cell stage embryo; brain; cerebellum; and cerebral cortex. Used to study infertility. Orthologous to human CDC23 (cell division cycle 23). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc23 |
| Official Name | CDC23 cell division cycle 23 [Source:MGI Symbol;Acc:MGI:1098815] |
| Ensembl ID | ENSMUSG00000024370 |
| Bio databases IDs | |
| Aliases | CDC23 cell division cycle 23 |
| Synonyms | 6030435O18, ANAPC8, APC8, CDC23 cell division cycle 23, cell division cycle 23, CUT23, D18Ertd243e, Rabkinesin6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc23 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- Tetratricopeptide repeats
- ubiquitin-protein transferase activity
- enzyme
- protein binding
- Anaphase promoting complex subunit 8 / Cdc23
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Cdc23 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- lung cancer
- systemic sclerosis
- anaplastic thyroid carcinoma
- anaplastic thyroid cancer
- epithelial thyroid cancer
role in cell
- quantity
- expression in
- degradation in
- mitosis
- extrusion
- misalignment
- chromosomal congression
- cell cycle progression
- misalignment in
- aneuploidization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear scaffolds
- meiotic spindles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc23 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- regulation of exit from mitosis
- positive regulation of mitotic metaphase/anaphase transition
- regulation of mitotic cell cycle
- mitotic cell cycle
- ubiquitin-dependent protein catabolic process
- cell division
- regulation of meiotic cell cycle
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- mitotic metaphase plate congression
- mitotic metaphase/anaphase transition
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- anaphase-promoting complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding