Ramp1 Gene Summary [Mouse]
Enables coreceptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in extracellular space. Predicted to be part of CGRP receptor complex. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and reproductive system. Orthologous to human RAMP1 (receptor activity modifying protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ramp1 |
| Official Name | receptor (calcitonin) activity modifying protein 1 [Source:MGI Symbol;Acc:MGI:1858418] |
| Ensembl ID | ENSMUSG00000034353 |
| Bio databases IDs | |
| Aliases | receptor (calcitonin) activity modifying protein 1 |
| Synonyms | 9130218E19RIK, receptor activity modifying protein 1, Receptor (calcitonin) activity modifying protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ramp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- extracellular domain
- calcitonin gene-related polypeptide receptor
- cytoplasmic domain
- Receptor activity modifying family
- transmembrane domain
- intracellular domain
- tail domain
- protein binding
- polypeptide hormone binding
- coreceptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- obesity
- insulin-dependent diabetes mellitus
- organismal death
- contact hypersensitivity
- hypoglycemia
- autosomal dominant polycystic kidney disease
- uterine serous papillary cancer
role in cell
- growth
- production in
- binding
- activation in
- proliferation
- migration
- sphere formation by
- internalization in
- mobilization
- receptor-mediated endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- Endoplasmic Reticulum
- synaptic membrane
- acrosome
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ramp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- angiogenesis
- calcium ion transport
- protein transport
- cellular response to hormone stimulus
- positive regulation of protein glycosylation
- regulation of G-protein coupled receptor protein signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- intracellular protein transport
- receptor internalization
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- protein binding
- calcitonin gene-related polypeptide receptor activity