Aggf1 Gene Summary [Mouse]
Predicted to enable identical protein binding activity and nucleic acid binding activity. Predicted to be involved in cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial cell proliferation. Predicted to be located in extracellular region and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; egg cylinder; genitourinary system; primitive streak; and sensory organ. Orthologous to human AGGF1 (angiogenic factor with G-patch and FHA domains 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aggf1 |
| Official Name | angiogenic factor with G patch and FHA domains 1 [Source:MGI Symbol;Acc:MGI:1913799] |
| Ensembl ID | ENSMUSG00000021681 |
| Bio databases IDs | |
| Aliases | angiogenic factor with G patch and FHA domains 1 |
| Synonyms | 2010009L17Rik, 2310029P06Rik, angiogenic factor with G-patch and FHA domains 1, FLJ10283, GPATC7, GPATCH7, HSU84971, HUS84971, Peg3, RGD1310888, VG5Q |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aggf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-patch domain
- FHA domain
- OCRE domain
- Forkhead associated domain
- protein binding
- identical protein binding
- forkhead associated (FHA) domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- vasculitis
- bleeding
- obesity
- Klippel-Trenaunay syndrome
- primary antiphospholipid antibody syndrome
role in cell
- apoptosis
- expression in
- formation in
- proliferation
- phosphorylation in
- adhesion
- size
- migration
- maturation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aggf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- cell adhesion
- positive regulation of endothelial cell proliferation
- vasculogenesis
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- protein binding