Cyb561a3 Gene Summary [Mouse]
Enables transmembrane ascorbate ferrireductase activity. Involved in intracellular iron ion homeostasis. Located in late endosome membrane and lysosomal membrane. Is expressed in ganglia; jaw bone; and neural retina. Orthologous to human CYB561A3 (cytochrome b561 family member A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyb561a3 |
| Official Name | cytochrome b561 family, member A3 [Source:MGI Symbol;Acc:MGI:2686925] |
| Ensembl ID | ENSMUSG00000034445 |
| Bio databases IDs | |
| Aliases | cytochrome b561 family, member A3 |
| Synonyms | 2310004G04Rik, CYBASC3, cytochrome b561 family member A3, cytochrome b561 family, member A3, LCYTB, MGC20446, RGD1304670 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cyb561a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metal ion oxidising oxidoreductase
- oxidoreduction-driven active transporter
- Cytochrome_b_N
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- proliferation
- damage in
- damage
- mitochondrial respiration in
- homeostasis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- lysosome
- lysosome membrane
- endosomal membrane
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cyb561a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- transmembrane transport
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- intracellular membrane-bounded organelle
- nucleolus
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity
- metal ion binding