Atf5 Gene Summary [Mouse]
Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in cerebellar granule cell precursor proliferation; circadian rhythm; and fat cell differentiation. Acts upstream of or within several processes, including negative regulation of apoptotic process; olfactory bulb interneuron development; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; endocrine gland; limb; sensory organ; and urinary system. Orthologous to human ATF5 (activating transcription factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atf5 |
| Official Name | activating transcription factor 5 [Source:MGI Symbol;Acc:MGI:2141857] |
| Ensembl ID | ENSMUSG00000038539 |
| Bio databases IDs | |
| Aliases | activating transcription factor 5 |
| Synonyms | activating transcription factor 5, AFTA, Atf7, ATFX, HMFN0395, ODA-10 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atf5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- heat shock protein binding
- Basic region leucine zipper
- chromatin binding
- protein binding
- sequence-specific DNA binding
- effector domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- kinase binding
- tubulin binding
- double-stranded DNA binding
- bZIP
- transcription factor activity
- basic region leucin zipper
Pathways
Biological processes and signaling networks where the Atf5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioma formation
- liver cancer
- androgenic alopecia
role in cell
- expression in
- proliferation
- differentiation
- apoptosis
- transcription in
- binding in
- growth
- survival
- G2/M phase transition
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- centrosome
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atf5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- negative regulation of cell proliferation
- post-embryonic development
- cerebellar granule cell precursor proliferation
- regulation of transcription, DNA-dependent
- fat cell differentiation
- circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
- regulation of centrosome cycle
- regulation of transcription from RNA polymerase II promoter
- olfactory bulb interneuron development
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding
- chromatin binding
- kinase binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity