Tmem109 Gene Summary [Mouse]
Predicted to enable voltage-gated monoatomic cation channel activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Predicted to be located in nuclear membrane and sarcoplasmic reticulum membrane. Predicted to be part of monoatomic ion channel complex. Is expressed in central nervous system; early conceptus; retina; and secondary oocyte. Orthologous to human TMEM109 (transmembrane protein 109). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem109 |
| Official Name | transmembrane protein 109 [Source:MGI Symbol;Acc:MGI:1915789] |
| Ensembl ID | ENSMUSG00000034659 |
| Bio databases IDs | |
| Aliases | transmembrane protein 109 |
| Synonyms | 1110006I15Rik, hSND3, MGC5508, Mitsugumin 23, SND3, transmembrane protein 109 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem109 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Negative regulator of p53/TP53
- voltage-gated ion channel
- ion channel
- cation channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- Mitochondria
- nuclear envelope
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem109 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to gamma radiation
- DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis
- negative regulation of programmed cell death
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- nuclear outer membrane
- ion channel complex
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- voltage-gated cation channel activity