ARL6IP5
ARL6IP5 Gene Summary
Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARL6IP5 |
| Official Name | ADP ribosylation factor like GTPase 6 interacting protein 5 [Source:HGNC Symbol;Acc:HGNC:16937] |
| Ensembl ID | ENSG00000144746 |
| Bio databases IDs | |
| Aliases | ADP ribosylation factor like GTPase 6 interacting protein 5, PRA1 domain family 3 |
| Synonyms | 5930404D22Rik,addicsin,addiscin,ADP-ribosylation factor-like 6 interacting protein 5,Adp ribosylation like factor 6 interacting protein 5,Aip-5,ARF like GTPase 6 interacting protein 5,DERP11,GTRAP3-18,hp22,HSPC127,jmx,JWA,PRA2,PRAF3,Yip6b |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PRA1 family protein
- ion channel binding
- protein binding
Pathways
Biological processes and signaling networks where the ARL6IP5 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR2
- RPS3A
- SLC1A1
- ARPC2
- LNPK
- SRC
- RPA2
- RPA3
- CLEC4E
- CDC42
disease
- neoplasia
- Parkinson disease
- mucopolysaccharidosis type IVB
- survival
- lung adenocarcinoma
- lung adenocarcinoma formation
- kyphosis
- osteoporosis
- melanoma
- melanoma cancer
regulated by
- bexarotene
- APP
- GRN
- IL1B
- IFNG
- TNF
- FSH
- benzo(a)pyrene
- arsenite
- LH
regulates
- glutathione
- ITGB3
- L-glutamic acid
- SNCA
- MEK
- Integrin alpha-V
role in cell
- growth
- expression in
- apoptosis
- function
- response by
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ARL6IP5 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- protein transport
- negative regulation of transport
- induction of apoptosis by oxidative stress
- learning or memory
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of L-glutamate transport
- negative regulation of mitochondrial membrane potential
- glutathione metabolic process
- positive regulation of apoptotic process
- cellular response to oxidative stress
- L-glutamate transport
- cellular response to organic cyclic compound
- positive regulation of stress-activated MAPK cascade
- protein localization in plasma membrane
CELLULAR COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytoskeleton
- membrane
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding