Mid1 Gene Summary [Mouse]
Predicted to enable several functions, including microtubule binding activity; protein homodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Located in cytoplasm and microtubule cytoskeleton. Is expressed in several structures, including alimentary system; brain; branchial arch; genitourinary system; and sensory organ. Used to study Opitz GBBB syndrome and microphthalmia. Human ortholog(s) of this gene implicated in Opitz GBBB syndrome. Orthologous to human MID1 (midline 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mid1 |
| Official Name | midline 1 [Source:MGI Symbol;Acc:MGI:1100537] |
| Ensembl ID | ENSMUSG00000035299 |
| Bio databases IDs | |
| Aliases | midline 1 |
| Synonyms | 61B3-R, BBBG1, DXHXS1141, FXY, GBBB, GBBB1, LOC637916, MIDIN, Midline1, OGS1, OS, OSX, RNF59, RP11-120D5.1, TRIM18, XPRF, ZNFXY |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mid1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- SPRY domain
- phosphoprotein binding
- Fibronectin type 3 domain
- identical protein binding
- B30.2 domain
- associated with SPRY domains
- G protein-coupled receptor kinase-interacting protein 1 C term
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- B-box zinc finger
- ubiquitin protein ligase binding
- zinc finger of C3HC4-type, RING
- enzyme binding
- Purple acid Phosphatase, N-terminal domain
- TRIM C-terminal subgroup One Signature domain
- Ring finger domain
- protein binding
- microtubule binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- FN3
- protein homodimerization
- Box B domain
- B subdomain from retinoblastoma
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked Opitz GBBB syndrome
- X-linked bulbospinal atrophy
- hereditary disorder
- Alzheimer disease
- hyperactive behavior
- Dandy-Walker syndrome
regulated by
- ASXL3
- imiquimod
- 5430416N02Rik
- lipopolysaccharide
- TGFB1
- IL3
- tretinoin
- 293t cells
- Z-LLL-CHO
- MAFB
role in cell
- signaling in
- phosphorylation in
- growth
- degradation in
- formation in
- ubiquitination in
- accumulation in
- synthesis in
- organization
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microtubule cytoskeleton
- Cytoplasm
- centrosome
- Golgi Apparatus
- microtubules
- cytosol
- cytoplasmic microtubule
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mid1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of microtubule cytoskeleton organization
- protein localization to microtubule
- negative regulation of microtubule depolymerization
- pattern specification process
- microtubule cytoskeleton organization
- positive regulation of stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- centriolar satellite
- spindle
- cytosol
- Golgi apparatus
- cytoplasmic microtubule
- microtubule associated complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- zinc ion binding
- protein homodimerization activity
- protein binding
- ubiquitin protein ligase binding
- phosphoprotein binding
- transferase activity
- enzyme binding
- microtubule binding