Ube2l6 Gene Summary [Mouse]
Enables ISG15 transferase activity. Acts upstream of or within ISG15-protein conjugation and modification-dependent protein catabolic process. Predicted to be active in nucleus. Is expressed in liver. Orthologous to human UBE2L6 (ubiquitin conjugating enzyme E2 L6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube2l6 |
| Official Name | ubiquitin-conjugating enzyme E2L 6 [Source:MGI Symbol;Acc:MGI:1914500] |
| Ensembl ID | ENSMUSG00000027078 |
| Bio databases IDs | |
| Aliases | ubiquitin-conjugating enzyme E2L 6 |
| Synonyms | 2810489I21Rik, RIG-B, UB2L6, UBCE8, UBCH8, Ubcm8, ubiquitin-conjugating enzyme E2L 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube2l6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin-conjugating enzyme
- ubiquitin-like protein transferase activity
- ubiquitin-protein transferase activity
- ISG15 conjugating enzyme
- UBCc_UEV
- ubiquitin binding
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube2l6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- idiopathic inflammatory myopathy
- neuroticism
- psoriasis
- systemic lupus erythematosus
- dermatomyositis
- complete testicular feminization syndrome
role in cell
- invasion by
- apoptosis
- growth
- cell death
- degradation in
- antigen presentation by
- replication in
- conjugation in
- isgylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube2l6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein polyubiquitination
- innate immune response
- ISG15-protein conjugation
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- ubiquitin protein ligase binding
- protein binding
- ubiquitin binding
- ISG15 ligase activity