Stk36 Gene Summary [Mouse]
Predicted to enable protein serine/threonine kinase activity and transcription corepressor binding activity. Involved in several processes, including cilium assembly; positive regulation of smoothened signaling pathway; and smoothened signaling pathway. Acts upstream of or within brain development and epithelial cilium movement involved in extracellular fluid movement. Located in cytoplasm. Is expressed in several structures, including central nervous system; sensory organ; skeleton; spleen; and testis. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human STK36 (serine/threonine kinase 36). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stk36 |
| Official Name | serine/threonine kinase 36 [Source:MGI Symbol;Acc:MGI:1920831] |
| Ensembl ID | ENSMUSG00000033276 |
| Bio databases IDs | |
| Aliases | serine/threonine kinase 36 |
| Synonyms | 1700112N14RIK, B930045J24, CILD46, FU, Fused, mKIAA1278, serine/threonine kinase 36, Stk36 (predicted) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Stk36 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- ATP binding
- transcription factor binding
- protein binding
- enzyme
- HEAT repeats
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- HEAT-like repeat
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Stk36 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- advanced colon cancer
- cutaneous melanoma
- metastatic colon cancer
- advanced rectal cancer
- stage III colon adenocarcinoma
- microsatellite instability high colon cancer
- metastatic cutaneous melanoma
- colorectal cancer
- metastatic rectal cancer
role in cell
- expression in
- proliferation
- migration
- invasion by
- assembly
- docetaxel sensitivity
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Stk36 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- positive regulation of smoothened signaling pathway
- post-embryonic development
- smoothened signaling pathway
- epithelial cilium movement
- axoneme assembly
- brain development
- protein phosphorylation
- regulation of sequence-specific DNA binding transcription factor activity
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- cytosol
- extracellular region
- cell projection
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity