Sec31a Gene Summary [Mouse]
Predicted to enable calcium-dependent protein binding activity and structural molecule activity. Predicted to be involved in COPII-coated vesicle cargo loading; endoplasmic reticulum organization; and response to calcium ion. Located in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum exit site. Human ortholog(s) of this gene implicated in Halperin-Birk syndrome. Orthologous to human SEC31A (SEC31 homolog A, COPII coat complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sec31a |
| Official Name | Sec31 homolog A (S. cerevisiae) [Source:MGI Symbol;Acc:MGI:1916412] |
| Ensembl ID | ENSMUSG00000035325 |
| Bio databases IDs | |
| Aliases | Sec31 homolog A (S. cerevisiae) |
| Synonyms | 1810024J13RIK, ABP125, ABP130, AU042160, HPBKS, HSPC275, HSPC334, KIAA0905, mSec31, NEDSOSB, SEC31, SEC31 homolog A, COPII coat complex component, SEC31L1, Sec31p, VAP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sec31a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- WD40 repeats
- WD40
- protein binding
- Single-stranded DNA binding protein, SSDP
- proline rich domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- intracellular membrane-bounded organelle
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
- endoplasmic reticulum exit sites
- Golgi buds
- transport vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sec31a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- response to calcium ion
- protein transport
- cargo loading into COPII-coated vesicle
- endoplasmic reticulum organization
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- cytoplasm
- intracellular membrane-bounded organelle
- ER to Golgi transport vesicle membrane
- cytosol
- vesicle coat
- endoplasmic reticulum
- endoplasmic reticulum exit site
- ER to Golgi transport vesicle
- COPII vesicle coat
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity
- calcium-dependent protein binding