Rmi1 Gene Summary [Mouse]
Predicted to enable nucleotide binding activity. Acts upstream of or within glucose homeostasis; reduction of food intake in response to dietary excess; and response to glucose. Predicted to be located in nucleoplasm. Predicted to be part of RecQ family helicase-topoisomerase III complex. Predicted to be active in nuclear body. Is expressed in embryo. Orthologous to human RMI1 (RecQ mediated genome instability 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rmi1 |
| Official Name | RecQ mediated genome instability 1 [Source:MGI Symbol;Acc:MGI:1921636] |
| Ensembl ID | ENSMUSG00000035367 |
| Bio databases IDs | |
| Aliases | RecQ mediated genome instability 1 |
| Synonyms | 4932432N11Rik, BLAP75, C9orf76, FAAP75, FLJ12888, RecQ mediated genome instability 1, RGD1310671 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rmi1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RecQ mediated genome instability protein
- Recq-mediated genome instability protein 1, C-terminal OB-fold
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- infection by HIV-1
regulates
- D-glucose
- BLM
role in cell
- formation
- proliferation
- formation in
- G2/M phase
- damage in
- sister chromatid exchange
- DNA damage response in
- camptothecin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rmi1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- response to glucose stimulus
- DNA replication
- glucose homeostasis
- double-strand break repair via homologous recombination
- resolution of recombination intermediates
- resolution of meiotic recombination intermediates
- reduction of food intake in response to dietary excess
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- RecQ helicase-Topo III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- protein binding