Tut1 Gene Summary [Mouse]
Predicted to enable several functions, including RNA binding activity; enzyme-substrate adaptor activity; and nucleotidyltransferase activity. Predicted to be involved in U6 snRNA 3'-end processing and co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway. Predicted to be located in cytosol and nucleolus. Predicted to be part of mRNA cleavage and polyadenylation specificity factor complex. Predicted to be active in nuclear speck. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human TUT1 (terminal uridylyl transferase 1, U6 snRNA-specific). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tut1 |
| Official Name | terminal uridylyl transferase 1, U6 snRNA-specific [Source:MGI Symbol;Acc:MGI:1917294] |
| Ensembl ID | ENSMUSG00000071645 |
| Bio databases IDs | |
| Aliases | terminal uridylyl transferase 1, U6 snRNA-specific |
| Synonyms | 2700038E08Rik, PAPD2, RBM21, STARPAP, TENT1, terminal uridylyl transferase 1, U6 snRNA-specific, TUTase, TUTase6, U6-TUTase, URLC6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tut1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- Zinc-finger double-stranded RNA-binding
- nucleotidyltransferase
- U6 snRNA binding
- protein binding activity, bridging
- enzyme binding
- U1 zinc finger
- enzyme
- protein binding
- Zinc-finger of C2H2 type
- RNA binding
- Cid1 family poly A polymerase
- mRNA 3' UTR binding
- Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
- RNA uridylyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
role in cell
- expression in
- accumulation in
- invasiveness
- 3' end processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tut1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA processing
- histone mRNA catabolic process
- RNA 3'-end processing
- mRNA 3'-end processing
- U6 snRNA 3'-end processing
Cellular Component
Where in the cell the gene product is active
- mRNA cleavage and polyadenylation specificity factor complex
- nuclear speck
- mitochondrion
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA uridylyltransferase activity
- U6 snRNA binding
- protein binding
- RNA binding
- metal ion binding
- enzyme binding
- mRNA 3'-UTR binding