Krt25 Gene Summary [Mouse]
Predicted to enable protein heterodimerization activity. Acts upstream of or within hair follicle morphogenesis and intermediate filament organization. Predicted to be located in keratin filament. Predicted to be active in cytoskeleton. Is expressed in naris; oral epithelium; and vibrissa. Human ortholog(s) of this gene implicated in autosomal recessive woolly hair 3. Orthologous to human KRT25 (keratin 25). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt25 |
| Official Name | keratin 25 [Source:MGI Symbol;Acc:MGI:1918060] |
| Ensembl ID | ENSMUSG00000035831 |
| Bio databases IDs | |
| Aliases | keratin 25 |
| Synonyms | 4631426H08Rik, ARWH3, CK-25, IRSa1, K25, Ka38, keratin 25, KRT24IRS1, KRT25A, mIRSa1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt25 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- TPR/MLP1/MLP2-like protein
- protein binding
- Intermediate filament protein
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Krt25 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt25 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- cytoskeleton organization
- hair follicle morphogenesis
- intermediate filament organization
- hair cycle
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- extracellular vesicular exosome
- keratin filament
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- structural molecule activity