Dlx3 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including cell surface receptor signaling pathway; epithelial cell differentiation; and hair follicle cell proliferation. Acts upstream of or within blood vessel development; odontogenesis of dentin-containing tooth; and placenta development. Located in cytoplasm and nucleus. Is expressed in several structures, including brain; branchial arch; genitourinary system; jaw; and sensory organ. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlx3 |
| Official Name | distal-less homeobox 3 [Source:MGI Symbol;Acc:MGI:94903] |
| Ensembl ID | ENSMUSG00000001510 |
| Bio databases IDs | |
| Aliases | distal-less homeobox 3 |
| Synonyms | AI4, distal-less homeobox 3, TDO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- Homeobox protein distal-less-like N terminal
- nuclear localization sequence
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- homeodomain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- benign neoplasia
- hypoplasia
- skin neoplasia
- leiomyomatosis
- carcinoma
- adenocarcinoma
- skin squamous cell carcinoma
- squamous cell skin cancer
- psoriasis
role in cell
- proliferation
- activation in
- migration
- expression in
- degradation in
- differentiation
- production in
- accumulation
- transcription in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- odontogenesis of dentin-containing tooth
- placenta development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- epithelial cell differentiation
- blood vessel development
- BMP signaling pathway
- Wnt receptor signaling pathway
- hair follicle morphogenesis
- gene expression
- odontoblast differentiation
- hair follicle cell proliferation
- hair cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity