Krt1 Gene Summary [Mouse]
Predicted to enable carbohydrate binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Acts upstream of or within establishment of skin barrier and negative regulation of inflammatory response. Located in keratin filament. Is active in cornified envelope. Is expressed in autopod; nose; skin; and tongue. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in KRT1-related nonepidermolytic palmoplantar keratoderma; epidermolytic hyperkeratosis; epidermolytic hyperkeratosis 1; epidermolytic palmoplantar keratoderma 2; and keratosis palmoplantaris striata 3. Orthologous to human KRT1 (keratin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt1 |
| Official Name | keratin 1 [Source:MGI Symbol;Acc:MGI:96698] |
| Ensembl ID | ENSMUSG00000046834 |
| Bio databases IDs | |
| Aliases | keratin 1 |
| Synonyms | AEI2, CK1, EHK, EHK1, EPPK, K1, Kb1, Keratin 1, Keratin 2-1, KERATIN, 67K type II CYTOSKELETAL, Keratin complex 2 basic gene 1, KRT1A, Krt-2.1, KRT2-1, Krt86, NEPPK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of epidermis
- protein binding
- carbohydrate binding
- Intermediate filament protein
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Krt1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- benign neoplasia
- epithelial neoplasia
- clear cell acanthoma
- skin neoplasia
- epidermolytic palmoplantar keratoderma type 2
- epidermolytic hyperkeratosis
- nonepidermolytic palmoplantar keratoderma
role in cell
- differentiation
- abnormal morphology
- binding
- abnormality
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- cornified envelope
- ficolin-1-rich granule lumen
- cytoskeleton
- cell surface
- Extracellular Space
- outer membranes
- cellular membrane
- Plasma Membrane
- desmosomes
- cytosol
- nucleoli
- nuclear scaffolds
- keratin intermediate filaments
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- complement activation, lectin pathway
- negative regulation of inflammatory response
- regulation of angiogenesis
- peptide cross-linking
- keratinization
- fibrinolysis
- protein heterotetramerization
- intermediate filament organization
- establishment of skin barrier
Cellular Component
Where in the cell the gene product is active
- nucleus
- cornified envelope
- extracellular space
- keratin filament
- extracellular vesicular exosome
- cytoskeleton
- cytoplasm
- blood microparticle
- membrane
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding
- protein heterodimerization activity
- signaling receptor activity
- carbohydrate binding