Tmem98 Gene Summary [Mouse]
Involved in several processes, including T-helper 1 cell differentiation; negative regulation of protein processing; and regulation of nervous system development. Located in endoplasmic reticulum membrane and extracellular space. Is expressed in pigmented retinal epithelium; spinal cord; and white matter. Human ortholog(s) of this gene implicated in nanophthalmos. Orthologous to human TMEM98 (transmembrane protein 98). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem98 |
| Official Name | transmembrane protein 98 [Source:MGI Symbol;Acc:MGI:1923457] |
| Ensembl ID | ENSMUSG00000035413 |
| Bio databases IDs | |
| Aliases | transmembrane protein 98 |
| Synonyms | 6530411B15Rik, DKFZp564K1964, Rwhs, TADA1, transmembrane protein 98 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem98 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem98 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T-helper 1 cell differentiation
- negative regulation of protein localization to nucleus
- negative regulation of protein processing
- negative regulation of myelination
- negative regulation of oligodendrocyte differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular space
- extracellular vesicular exosome
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding