Gramd1c Gene Summary [Mouse]
Enables cholesterol binding activity and cholesterol transfer activity. Involved in cellular response to cholesterol. Located in endoplasmic reticulum membrane; endoplasmic reticulum-plasma membrane contact site; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and ventricular layer. Orthologous to human GRAMD1C (GRAM domain containing 1C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gramd1c |
| Official Name | GRAM domain containing 1C [Source:MGI Symbol;Acc:MGI:2443024] |
| Ensembl ID | ENSMUSG00000036292 |
| Bio databases IDs | |
| Aliases | GRAM domain containing 1C |
| Synonyms | 4921521N14Rik, GRAM domain containing 1C, RGD1305433 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gramd1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- cholesterol binding
- protein binding
- Pleckstrin homology-like domain
- VAD1 Analog of StAR-related lipid transfer domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- endoplasmic reticulum membrane
- organelle membrane contact site
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gramd1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to cholesterol
- intracellular sterol transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding