Fbxw2 Gene Summary [Mouse]
Located in cytoplasm. Is expressed in central nervous system; retina; and urinary system. Orthologous to human FBXW2 (F-box and WD repeat domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Fbxw2 |
| Official Name | F-box and WD-40 domain protein 2 [Source:MGI Symbol;Acc:MGI:1353435] |
| Ensembl ID | ENSMUSG00000035949 |
| Bio databases IDs | |
| Aliases | F-box and WD-40 domain protein 2 |
| Synonyms | 2700071L08RIK, F-box and WD-40 domain protein 2, F-box and WD repeat domain containing 2, FBW2, Fwd2, MD6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxw2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- WD40 repeats
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box-like
- WD domain, G-beta repeat
- WD40
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxw2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- proteolysis
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding