Polr1h Gene Summary [Mouse]
Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to contribute to DNA-directed RNA polymerase activity. Predicted to be involved in termination of RNA polymerase I transcription. Predicted to be located in nucleoplasm. Predicted to be part of RNA polymerase I complex. Is expressed in early conceptus; genitourinary system; and limb. Orthologous to human POLR1H (RNA polymerase I subunit H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Polr1h |
| Official Name | RNA polymerase I subunit H [Source:MGI Symbol;Acc:MGI:1913386] |
| Ensembl ID | ENSMUSG00000036315 |
| Bio databases IDs | |
| Aliases | RNA polymerase I subunit H |
| Synonyms | 1110014N07RIK, A12.2, HTEX-6, hZR14, RNA polymerase I subunit H, Rpa12, TCTEX6, TEX6, ZNRD1, ZR14 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr1h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription factor S, archaeal
- Zn-ribbon
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- breast cancer
- multiple sclerosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- bipolar disorder
- attention deficit hyperactivity disorder
- pervasive developmental disorder
- major depression
- endometrial cancer
role in cell
- expression in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr1h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- termination of RNA polymerase I transcription
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- DNA-directed RNA polymerase I complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- zinc ion binding
- protein binding
- RNA polymerase I activity