POLR1H Gene Summary [Human]
This gene encodes a DNA-directed RNA polymerase I subunit. The encoded protein contains two potential zinc-binding motifs and may play a role in regulation of cell proliferation. The encoded protein may be involved in cancer and human immunodeficiency virus progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Retained Intron |
| Official Symbol | POLR1H |
| Official Name | RNA polymerase I subunit H [Source:HGNC Symbol;Acc:HGNC:13182] |
| Ensembl ID | ENSG00000066379 |
| Bio databases IDs | |
| Aliases | RNA polymerase I subunit H |
| Synonyms | 1110014N07RIK, A12.2, HTEX-6, hZR14, RNA polymerase I subunit H, Rpa12, TCTEX6, TEX6, ZNRD1, ZR14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR1H often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription factor S, archaeal
- Zn-ribbon
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- breast cancer
- multiple sclerosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- bipolar disorder
- attention deficit hyperactivity disorder
- pervasive developmental disorder
- major depression
- endometrial cancer
role in cell
- expression in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR1H gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- termination of RNA polymerase I transcription
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- DNA-directed RNA polymerase I complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- zinc ion binding
- protein binding
- RNA polymerase I activity