Fam13b Gene Summary [Mouse]
Predicted to enable GTPase activator activity. Predicted to be involved in signal transduction. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system; and integumental system. Orthologous to human FAM13B (family with sequence similarity 13 member B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fam13b |
| Official Name | family with sequence similarity 13, member B [Source:MGI Symbol;Acc:MGI:2447834] |
| Ensembl ID | ENSMUSG00000036501 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 13, member B |
| Synonyms | 2610024E20Rik, ARHGAP49, C5orf5, FAM13B1, family with sequence similarity 13 member B, family with sequence similarity 13, member B, KHCHP, N61, RGD1310484 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fam13b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- GTPase activator
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- ovarian cancer
- cardioembolic stroke
- bladder cancer
- myocardial infarction
- arrhythmia
- atrial fibrillation
- male pattern hair loss
- survival
role in cell
- binding in
- expression in
- migration
- proliferation
- production in
- killing
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fam13b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- GTPase activator activity