Ascc3 Gene Summary [Mouse]
Predicted to enable 3'-5' DNA helicase activity and ATP hydrolysis activity. Predicted to be involved in several processes, including DNA alkylation repair; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be part of DNA repair complex and RQC-trigger complex. Predicted to be active in cytosolic ribosome and nucleus. Is expressed in embryo. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human ASCC3 (activating signal cointegrator 1 complex subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ascc3 |
| Official Name | activating signal cointegrator 1 complex subunit 3 [Source:MGI Symbol;Acc:MGI:1925237] |
| Ensembl ID | ENSMUSG00000038774 |
| Bio databases IDs | |
| Aliases | activating signal cointegrator 1 complex subunit 3 |
| Synonyms | activating signal cointegrator 1 complex subunit 3, ASC1p200, B630009I04RIK, BC023451, D430001L07RIK, D630041L21, DJ467N11.1, HELIC1, MRT81, RNAH |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ascc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sec63 Brl domain
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- Domain of unknown function in Sec63p, Brr2p and other proteins
- enzyme
- protein binding
- DEAD-like helicases superfamily
- ATPase
- P-loop containing Nucleoside Triphosphate Hydrolases
- DNA helicase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- COVID-19
- insomnia
- autosomal recessive intellectual developmental disorder type 81
- organismal death
- major depression
- non-small cell lung cancer
- depressive disorder
- kidney stones
- neuroticism
role in cell
- migration
- survival
- proliferation
- growth
- expression in
- invasion by
- apoptosis
- disassembly
- ubiquitination in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- ribosome
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ascc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- DNA dealkylation involved in DNA repair
- rescue of stalled ribosome
- DNA duplex unwinding
- ribosome disassembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosolic ribosome
- nuclear speck
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- 3'-5' DNA helicase activity