Ttll7 Gene Summary [Mouse]
Enables tubulin-glutamic acid ligase activity. Involved in protein polyglutamylation. Located in 9+0 non-motile cilium and ciliary basal body. Is expressed in 1-cell stage embryo and 8-cell stage embryo. Orthologous to human TTLL7 (tubulin tyrosine ligase like 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Ttll7 |
| Official Name | tubulin tyrosine ligase-like family, member 7 [Source:MGI Symbol;Acc:MGI:1918142] |
| Ensembl ID | ENSMUSG00000036745 |
| Bio databases IDs | |
| Aliases | tubulin tyrosine ligase-like family, member 7 |
| Synonyms | 1110049N09Rik, 4921517B04Rik, C630030B20, LOC108350133, mTTLL7, RGD1566117, tubulin tyrosine ligase like 7, tubulin tyrosine ligase-like family, member 7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttll7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-tubulin binding
- acid-D-amino acid ligase
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- alpha-tubulin binding
- enzyme
- protein binding
- bZIP
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- obesity
- weight gain
- metabolic syndrome X
- atherosclerosis
- pervasive developmental disorder
- peripheral arterial disease
regulates
- beta tubulin
- BAP1
role in cell
- outgrowth
- abnormal morphology
- glutamylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- non-motile cilium
- somatodendritic region
- basal bodies
- cytosol
- perikaryon
- dendrites
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttll7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyglutamylation
- nervous system development
- cell differentiation
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- dendrite
- cilium
- cytosol
- perikaryon
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- ATP binding
- metal ion binding
- beta-tubulin binding
- tubulin-glutamic acid ligase activity
- alpha-tubulin binding