Klhl13 Gene Summary [Mouse]
Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including brain; diaphragm; limb segment; skeletal musculature; and spinal cord mantle layer. Orthologous to human KLHL13 (kelch like family member 13). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl13 |
| Official Name | kelch-like 13 [Source:MGI Symbol;Acc:MGI:1914705] |
| Ensembl ID | ENSMUSG00000036782 |
| Bio databases IDs | |
| Aliases | kelch-like 13 |
| Synonyms | 1200009K10Rik, BKLHD2, D130072F20Rik, kelch-like 13, kelch-like family member 13 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klhl13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- ubiquitin-protein transferase activity
- BTB/POZ domain
- enzyme
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klhl13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- regulation of cytokinesis
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding