Ppp1r16b Gene Summary [Mouse]
Predicted to enable enzyme inhibitor activity and myosin phosphatase regulator activity. Acts upstream of or within establishment of endothelial barrier. Predicted to be located in nuclear speck; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including brain; eye; heart; hemolymphoid system; and spinal cord. Orthologous to human PPP1R16B (protein phosphatase 1 regulatory subunit 16B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r16b |
| Official Name | protein phosphatase 1, regulatory subunit 16B [Source:MGI Symbol;Acc:MGI:2151841] |
| Ensembl ID | ENSMUSG00000037754 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 16B |
| Synonyms | ANKRD4, C130078N17RIK, LOC684098, protein phosphatase 1 regulatory subunit 16B, protein phosphatase 1, regulatory subunit 16B, TIMAP, Wdt4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp1r16b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- phosphatase
- Ankyrin repeats (3 copies)
- protein phosphatase regulator
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diverticular disease
- schizophrenia
- alcoholic pancreatitis
role in cell
- activation in
- phosphorylation in
- proliferation
- binding in
- differentiation
- survival
- dephosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- perinuclear region
- Nucleus
- plasma membrane projections
- nuclear speckles
- cellular protrusions
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp1r16b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein kinase B signaling cascade
- regulation of filopodium assembly
- positive regulation of protein dephosphorylation
- negative regulation of protein dephosphorylation
- positive regulation of endothelial cell proliferation
- establishment of endothelial barrier
- regulation of protein dephosphorylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- nuclear speck
- cell projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- enzyme inhibitor activity
- myosin phosphatase regulator activity
- protein phosphatase regulator activity